Racial susceptibility for QT prolongation in acute drug overdoses
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چکیده
منابع مشابه
Drug induced QT prolongation.
The drug-induced QT prolongation predisposes to development of torsades de pointes (TdP) ventricular tachycardia and sudden death. The association between specific drug and development of TdP is difficult to document, therefore, QT prolongation is considered as a surrogate marker of the proarrhythmia risk. Most of the drugs prolong QT interval usually by blocking the potassium IKr current or al...
متن کاملDrug-Induced Prolongation of the QT Interval
N Engl J Med 2004;350:1013-22. Copyright © 2004 Massachusetts Medical Society. n the past decade, the single most common cause of the withdrawal or restriction of the use of drugs that have already been marketed has been the prolongation of the QT interval associated with polymorphic ventricular tachycardia, or torsade de pointes (Fig. 1), which can be fatal. 1 Nine structurally unrelated drugs...
متن کاملDrug-induced prolongation of the QT interval.
N Engl J Med 2004;350:1013-22. Copyright © 2004 Massachusetts Medical Society. n the past decade, the single most common cause of the withdrawal or restriction of the use of drugs that have already been marketed has been the prolongation of the QT interval associated with polymorphic ventricular tachycardia, or torsade de pointes (Fig. 1), which can be fatal. 1 Nine structurally unrelated drugs...
متن کاملQT Prolongation and Oncology Drug Development.
Many pharmaceutical agents interact with cardiac ion channels resulting in abnormal ventricular repolarization and prolongation of the QT interval. In rare circumstances, this has resulted in the development of the potentially life-threatening arrhythmia, torsades de pointes. It is recognized, however, that accurate measurement of the QT interval is challenging, and it is a poor predictor for t...
متن کاملDrug-induced QT prolongation journal article
Background: Although QT prolongation is associated with increased risk of torsade de pointes (TdP), the precise relationship is not well defined. Aim: To evaluate the performance of a QT nomogram in assessing the risk of TdP from QT– RR combinations. Design: Systematic review. Methods: We systematically searched MEDLINE/ EMBASE for cases of drug-induced TdP. Controls were patients taking non-ca...
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ژورنال
عنوان ژورنال: Journal of Electrocardiology
سال: 2014
ISSN: 0022-0736
DOI: 10.1016/j.jelectrocard.2013.12.002